Sodium Hydroxide → 5-(2,4-dichloro-5-(5-fluoropyridin-2-yl)benzamido)-1-phenyl-1H-pyrazole-3-carboxylic acid

Participants

Reaction Steps

To a suspension of ethyl 5-(2,4-dichloro-5-(5-fluoropyridin-2-yl)benzamido)-1-phenyl-1H-pyrazole-3-carboxylate (Example 116, 822 mg, 1.65 mmol) in ethanol (15 mL) was added 2M aqueous sodium hydroxide (4.1 mL, 8.23 mmol) and the reaction was stirred at room temperature for 1 hour. The reaction mixture was concentrated in vacuo. The residue was diluted with water (25 mL) and neutralised with 2M aqueous hydrochloric acid. The resultant solid was filtered, washed with water and dried in vacuo to afford the title compound as a white solid (700 mg, 90%).

Provenance & Evidence