Hydrochloric Acid → 5-(2,4-dichloro-5-(3-fluoropyridin-2-yl)benzamido)-1-phenyl-1H-pyrazole-3-carboxylic acid

Participants

Reaction Steps

To a suspension of ethyl 5-(2,4-dichloro-5-(3-fluoropyridin-2-yl)benzamido)-1-phenyl-1H-pyrazole-3-carboxylate (Example 122A, 58.3 g, 0.117 mol) in IMS (580 mL), was added 2M aqueous sodium hydroxide solution (176 mL, 0.352 mol) and the reaction stirred at room temperature for 5 hours. The reaction mixture was diluted with water (600 mL) and acidified to pH1 with hydrochloric acid solution (40 mL, 36%). The resulting solid was filtered and washed with water (50 mL) to give the title compound as a white solid (53.1 g, 97%).

Provenance & Evidence