Hydrochloric Acid → 5-(2,4-dichloro-5-(pyridin-2-yl)benzamido)-1-phenyl-1H-pyrazole-3-carboxylic acid

Participants

Reaction Steps

To a solution of ethyl 5-(2,4-dichloro-5-(pyridin-2-yl)benzamido)-1-phenyl-1H-pyrazole-3-carboxylate (Example 124, 2.5 g, 5.19 mmol) in industrial methylated spirit (50 mL) was added a 1M LiOH solution in water (26 mL, 26 mmol) and the reaction was stirred at room temperature for 3 hours. The reaction was acidified with 2M HCl (aq) (13 mL, 26 mmol) to afford a precipitate that was filtered and washed with industrial methylated spirit to afford the title compound (1.96 g, 83%).

Provenance & Evidence