反应详情

温度

50 °C

To a suspension of methyl 2,4-dichloro-5-(5-fluoropyridin-2-yl)benzoate (Preparation 34, 1 g, 3.33 mmol) in methanol (20 mL) was added 2M aqueous sodium hydroxide solution (3.3 mL, 6.66 mmol) and the reaction was heated at 50° C. for 1 hour. The reaction was concentrated in vacuo and the residue stirred with 2M aqueous hydrochloric acid (30 mL). The resulting precipitate was filtered, washed with water and dried in vacuo to afford the title compound as a white solid (900 mg, 84%).

1. concentrationThe reaction was concentrated in vacuo
2. filtrationThe resulting precipitate was filtered
3. washwashed with water
4. customdried in vacuo