反应详情

To a suspension of potassium (Z)-1-cyano-3-ethoxy-3-oxoprop-1-en-2-olate (3.73 g, 20.82 mmol) in ethanol (100 mL) was added (3-(benzyloxy)phenyl)hydrazine hydrochloride (Preparation 61, 5.22 g, 20.82 mmol) and the reaction was heated at reflux for 24 hours. The reaction was cooled to room temperature, the solid was filtered and the filtrate was concentrated in vacuo. The residue was purified using silica gel column chromatography eluting with 20-40% EtOAc in heptanes to afford the title compound (4.76 g, 68%).

1. temperaturethe reaction was heated
2. temperatureat reflux for 24 hours
3. filtrationthe solid was filtered
4. concentrationthe filtrate was concentrated in vacuo
5. customThe residue was purified
6. washeluting with 20-40% EtOAc in heptanes