Triethylamine → HCID 118274125, compound

Participants

Reaction Steps

To a suspension of Example 48 (60 mg, 0.17 mmol) in dichloromethane (5 mL) was added triethylamine (0.1 mL, 0.68 mmol) and methanesulfonyl chloride (30 mg, 0.25 mmol) and the mixture was stirred at room temperature overnight. Purification by flash chromatography on silica gel (Teledyne CombiFlash Rf, 0-15% methanol in 2:1 ethyl acetate/hexane) provided the title compound. 1H NMR (400 MHz, DMSO-d6): δ 2.71 (s, 1H), 2.89 (s, 3H), 2.97 (s, 3H), 3.36-3.41 (m, 2H), 3.94-3.95 (m, 2H), 4.08 (s, 2H), 5.90 (s, 1H), 7.28-7.32 (m, 1H), 7.39 (dd, J=9.16, 5.49 Hz, 1H), 7.63-7.67 (m, 1H), 8.27 (d, J=4.88 Hz, 1H), 11.72 (s, 1H). MS (ESI+) m/z 411 (M+H)+.

Provenance & Evidence