4-Toluenesulfonyl chloride → HCID 118274348, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of Example 127A (1 g, 5.54 mmol) in toluene (10 mL) was added p-toluenesulfonyl chloride (1.584 g, 8.31 mmol) and tetrabutylammonium hydrogensulfate (0.188 g, 0.554 mmol). The mixture was cooled to 0° C., and a solution of sodium hydroxide (0.554 g, 13.84 mmol) in water (2 mL) was added. The mixture was stirred at room temperature overnight, and partitioned between ethyl acetate and water. The organic phase was washed with water and concentrated. The residue was triturated with 10% ethyl acetate in heptane and filtered to provide the title compound. MS (ESI+) m/z 335 (M+H)+.

Provenance & Evidence