Hydrochloric Acid → HCID 117899594, compound

Participants

Reaction Steps

A 4 M solution of hydrogen chloride in EtOAc (5 mL) was added to a suspension of tert-butyl 4-(2-{4-[2-chloro-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2-(trifluoromethyl)phenoxy}ethyl)piperidine-1-carboxylate (500 mg) in EtOAc (5 mL), and the mixture was stirred at the same temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, whereby 2-chloro-7-(2-methoxyethyl)-4-{4-[2-(piperidin-4-yl)ethoxy]-3-(trifluoromethyl)phenyl}-7H-pyrrolo[2,3-d]pyrimidine monohydrochloride (445 mg) was obtained as a pale yellow solid.

Provenance & Evidence