Hydrochloric Acid → HCID 117899593, compound

Participants

Reaction Steps

A 4 M solution of hydrogen chloride in EtOAc (0.12 mL) was added to a solution of 4-{4-[2-(1-ethylpiperidin-4-yl)ethoxy]-3-(trifluoromethyl)phenyl}-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile (80 mg) in CH2Cl2 (1.5 mL) at room temperature, and the mixture was stirred at the same temperature for 0.5 hours. The reaction mixture was concentrated under reduced pressure, and diisopropyl ether was added to the residue. The precipitate was washed with diisopropyl ether, and collected by filtration, whereby 4-{4-[2-(1-ethylpiperidin-4-yl)ethoxy]-3-(trifluoromethyl)phenyl}-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile monohydrochloride (50 mg) was obtained as a pale yellow solid.

Provenance & Evidence