Dimethylformamide → HCID 117899577, compound

Participants

Reaction Conditions

Reaction Steps

Isobutylene oxide (38 μL) and N,N-diisopropylethylamine (73 μL) were added to a solution of 7-methyl-4-[6-{[1-(piperidin-4-yl carbonyl)piperidin-4-yl]methoxy}-5-(trifluoromethyl)pyridin-3-yl]-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile monohydrochloride (120 mg) in EtOH (2.4 mL)-DMF (0.5 mL) at room temperature, and the mixture was stirred at 60° C. overnight. The reaction mixture was cooled to room temperature, and EtAOc and water were added thereto. Extraction was performed on the mixture using EtOAc, and the extract was washed with saturated brine. The organic layer was dried over MgSO4 and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (Hex:CHCl3=70:30 to 20:80), whereby 4-{6-[(1-{[1-(2-hydroxy-2-methylpropyl)piperidin-4-yl]carbonyl}piperidin-4-yl)methoxy]-5-(trifluoromethyl)pyridin-3-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-2-carbonitrile (93 mg) was obtained as a solid.

Provenance & Evidence