Sodium Azide → HCID 86723047, compound

HRID 522335Notes

Reaction equation

HRID 522335 reaction equation
[N-:1]=[N+:2]=[N-:3].[Na+].[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[C:16]([CH:17]([CH3:19])[CH3:18])=[C:15]([C:20](Cl)=[O:21])[N:14]=[N:13]2)=[CH:8][CH:7]=1>CC(C)=O.C(Cl)Cl>[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[C:16]([CH:17]([CH3:19])[CH3:18])=[C:15]([C:20]([N:1]=[N+:2]=[N-:3])=[O:21])[N:14]=[N:13]2)=[CH:8][CH:7]=1

Participants

5

Reactant 2

HCID 33557Sodium AzideHCID 86723046HCID 86723046, compound

Product 1

HCID 86723047HCID 86723047, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 6344DichloromethaneSolvent

Procedure

Sodium azide (610 mg in 2.5 mL of H2O, 9.39 mmol) was added to a cooled (0° C.) solution of 1-(4-chlorophenyl)-5-isopropyl-triazole-4-carbonyl chloride in acetone (7.5 mL). The resulting mixture was stirred at room temperature for 30 min, diluted with CH2Cl2 (100 mL), washed with water (50 mL) and brine (50 mL), dried (MgSO4), and concentrated in vacuo to give the crude 1-(4-chlorophenyl)-5-isopropyl-triazole-4-carbonyl azide (777 mg) which was used in the next step without further purification.

Workup

  1. washwashed with water (50 mL) and brine (50 mL)
  2. dry with materialdried (MgSO4)
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2fb246d263504a29a01cb173299f7dc6
Source dataset
uspto-grants-2016_05
Patent number
US09328116B2

Reaction notes

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