HCID 14806086, compound → 1896752-94-5

HRID 522347Notes

Reaction equation

HRID 522347 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1([C:10]([OH:12])=[O:11])[CH2:8][CH:7]2[CH2:9][CH:4]1[CH:5]=[CH:6]2>C1(C)C=CC=CC=1.[Pd]>[F:1][C:2]([F:13])([F:14])[C:3]1([C:10]([OH:12])=[O:11])[CH2:8][CH:7]2[CH2:9][CH:4]1[CH2:5][CH2:6]2

Participants

4

Reactant 1

HCID 14806086HCID 14806086, compound

Product 1

HCID 588234931896752-94-5Yield 32%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 1140TolueneSolvent

Procedure

2-Trifluoromethylbicyclo[2,2,1]hepta-5-ene-2-carboxylic acid (20) obtained in Synthesis Example 1-1-1 was stirred in a toluene solvent in the presence of 5% Pd/C catalyst at room temperature under hydrogen atmosphere to obtain 2-trifluoromethylbicyclo[2,2,1]heptane-2-carboxylic acid. In the same synthetic routes as in Synthesis Example 1-1-2 to 1-1-3 except for using the carboxylic acid as the starting material to obtain 3.9 g (four-step yield: 32%) of Q-3.

Sources & evidence

ORD record
ord-b1c42313ed5e4c9f83aaf7418ef966a2
Source dataset
uspto-grants-2016_05
Patent number
US09329476B2

Reaction notes

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