反应详情

N-bromosuccinimide (2.21 g) was added to the solution of 2,4-dihydroxyquinoline (2 g) in DCM (50 ml). The mixture was stirred at room temperature for 3 days. The mixture was filtrated and the solid was triturated with isopropanol. After filtration, toluene was added to the solid and the solvent was evaporated under reduced pressure to give the desired product (1.92 g) as a beige solid. LRMS (ES+) m/z 240.1 (M+H)+.

1. filtrationThe mixture was filtrated
2. customthe solid was triturated with isopropanol
3. filtrationAfter filtration, toluene
4. additionwas added to the solid
5. customthe solvent was evaporated under reduced pressure