HCID 117598889, compound → HCID 178421216, compound

Participants

Reaction Steps

To a solution of (3aR,7S,10S,12R,21E,24aS)-19-(benzyloxy)-7-cyclopentyl-3a-methyl-5,8-dioxo-1,2,3,3a,5,6,7,8,11,12,20,23,24,24a-tetradecahydro-10H-9,12-methanocyclopenta[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoline-10-carboxylic acid (synthesized as described in Example 1 with intermediates B7 and C3) (113 mg) in ethyl acetate (5 ml) was added 10% Pd/C (20 mg) and the mixture was stirred for 18 hours under hydrogen atmosphere. After exchanging the atmosphere for nitrogen, the reaction mixture was filtered and concentrated to give the desired product (93 mg). LRMS (ES+) M/Z (M+H)+ 594.7.

Provenance & Evidence