Pyrrolidine → HCID 117599154, compound

Participants

Reaction Steps

To a solution of {[(3aR,7S,10S,12R,21E,24aS)-7-cyclopentyl-10-({(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}carbamoyl)-5,8-dioxo-1,2,3,3a,5,6,7,8,11,12,20,23,24,24a-tetradecahydro-10H-9,12-methanocyclopenta[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinolin-19-yl]oxy}acetic acid (Example 66) (27 mg) in DMF (0.5 mL) was added pyrrolidine (5.27 μL), DIPEA (0.028 mL) and HATU (14.53 mg). The reaction mixture was stirred at room temperature for 15 minutes. The reaction was quenched with water and 5% KHSO4 until pH=3. More water was added and the mixture was stirred 5 minutes. The white solid was filtered (washed with water). This solid was dissolved in ethyl acetate and the mixture was dried over magnesium sulfate, filtered and concentrated to afford the desired product (26 mg). HRMS (ES+) m/z 901.4109 (M+H)+.

Provenance & Evidence