1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 117599013, compound

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Reaction Steps

To a solution of the acid from Step 2 (46.6 mg) and N,N-dimethylsulfuric diamide (29.3 mg) in DMF (1 mL) was added DIPEA (52 DMAP (28.8 mg) and DBU (40 μL). The reaction mixture was stirred 5 minutes before adding HATU (26.9 mg). The mixture was stirred at room temperature for 18 hours. The reaction mixture was diluted with Et2O and ethyl acetate and quenched with water and acetic acid (pH=4). The mixture was extracted with diethyl ether (3×). The combined organic phases were washed with water (3×), dried over magnesium sulfate, filtered and concentrated. Purification by flash chromatography (ISCO, 0 to 10% methanol in dichloromethane) afforded the desired product (34.2 mg). LRMS (ES+) m/z 896.50 (M+H)+. By following the procedures outlined in Example 106 and using the appropriate reagent (depicted below the structure as Rg.), the following compounds were prepared.

Provenance & Evidence