HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 89590826, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 131735532 | HCID 131735532 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 89590826 | HCID 89590826 | — |
Reaction Steps
To a solution of the product of step 3 in DMF (52 mL) at 0° C. was added DIPEA (3.1 mL) and HATU (1.64 g). The mixture was stirred at room temperature for 2 hours until disappearance of the starting material. The reaction mixture was diluted with Et2O and quenched with water and HCl (1N). The mixture was extracted (3×) with ether. The combined organic phases were washed with water then brine, dried over sodium sulfate, filtered and concentrated. Purification by flash chromatography (ISCO, 0 to 100% ethyl acetate in hexanes) afforded the desired product (1.3 g). LRMS (ES+) m/z 640.45 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328138B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-8cb4e26752214cb481305afec4d56a7e |
| Source note | uspto-grants-2016_05 |