Potassium Iodide → HCID 89590921, compound

Participants

Reaction Conditions

Reaction Steps

The amine from Step 2 (70.9 mg) was dissolved in DMF (0.3 mL) and triethylamine (53 μl), potassium iodide (1.6 mg) and 2-bromoethyl methyl ether (20 μl) were added sequentially. The reaction mixture was stirred at 60° C. for 24 hours. The reaction mixture was then cooled to room temperature and quenched with a saturated solution of sodium bicarbonate. The mixture was extracted (3×) with ethyl acetate and the combined organics were dried with sodium sulfate, filtered and concentrated. Purification of the residue by flash chromatography (ISCO, 0 to 10% methanol in DCM) gave the desired product (50.6 mg). LRMS (ES+) m/z 695.5 (M+H)+.

Provenance & Evidence