Acetic Acid → HCID 89590959, compound

Participants

Reaction Steps

A round-bottom flask was charged with the product of step 6 (450 mg, 0.651 mmol) and lithium hydroxide monohydrate (137 mg, 3.26 mmol). MeOH (2171 μl), THF (2171 μl) and water (2171 μl) were successively added and the mixture was stirred at room temperature LCMS showed complete reaction after 2 hours. The reaction was quenched by addition of acetic acid (373 μl, 6.51 mmol). Water was added (20 mL) and the mixture was extracted with dichloromethane (2×20 mL) and ethyl acetate (20 mL). The combined organic extracts were dried over magnesium sulfate, filtered and concentrated in rotavap. Residual acetic acid was azeotropically removed with toluene to give the title compound as a crude product (450 mg, 0.665 mmol, 102% yield) as a white powder. No further purification was carried out.

Provenance & Evidence