Tributylvinyltin → HCID 89590961, compound

Participants

Role	Name	HCID	Charge
Reactant	Tributylvinyltin	HCID 81998	—
Reactant	HCID 89590960	HCID 89590960	—
Catalyst	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
Catalyst	HCID 178418397	HCID 178418397	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 89590961	HCID 89590961	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

To a solution of the product from Example 244 step 1 (100 mg, 0.146 mmol) in dioxane (3 ml) was added tributyl(vinyl)stannane (92 mg, 0.292 mmol), copper (I) iodide (5.55 mg, 0.029 mmol) and tetrakis (33.7 mg, 0.029 mmol). After purging with N2 for 5 min, the reaction was stirred at 80° C. for 16 hours. After cooling to room temperature, water was added and the reaction was extracted with ethyl acetate, washed with brine, dried (Na2SO4) and concentrated. Purification by PTLC (30% EtOAc/hexane) provided the desired compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09328138B2
Source dataset	uspto-grants-2016_05
ORD ID	ord-86fcb7fc8b5b4c6794f8639c4f8ab67d
Source note	uspto-grants-2016_05