Lithium hydroxide, monohydrate → HCID 117599121, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product from Step 1 (1.88 g, 5.81 mmol) in THF (20 ml) and MeOH (10 mL) was added an aq. 2M solution of lithium hydroxide monohydrate (14.53 ml, 29.1 mmol). The reaction was stirred at 50° C. for 20 hours at which stage TLC indicated no more starting material. The reaction was treated with 10% aq. KHSO4 and extracted with EtOAc. The organic fractions were washed with brine, dried over sodium sulfate, evaporated and dried to provide the desired compound, which was used for the next step without purification.

Provenance & Evidence