HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 4-PHENYLAMINO-BENZONITRILE
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Benzonitrile, 4-bromo- | HCID 12162 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-PHENYLAMINO-BENZONITRILE | HCID 9964342 | — |
Reaction Steps
Under a flow of argon, in a 300 mL-recovery flask, 20 g of 4-bromobenzonitrile, 30 mL of aniline, 1.50 g of tris(dibenzylideneacetone)dipalladium(0)[Pd2(dba)3], 2.1 g of 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl[BINAP], 21.1 g of sodium tert-butoxide and 313 mL of dehydrated toluene were placed, and reacted at 85° C. for 6 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09331285B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-0ae08bf92c33462f83269f61884b29b8 |
| Source note | uspto-grants-2016_05 |