Cyanamide → HCID 178480751, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamine (275 mg, 1 mmol) in HCl 6N (1 mL), cyanamide (336 mg, 8.0 mmol) was added and the reaction was stirred at 60° C. for 1 hours. The mixture was cooled down to room temperature, diluted with H2O (3 mL), extracted with DCM (10 mL). NaOH 2N was added to pH>11. The aqueous phase was extracted with Et2O (3×10 mL), dried over Na2SO4 and concentrated. The residue was crystallized from Et2O to give the title compound (240 mg, 76% yield) as a white solid.

Provenance & Evidence