HCID 68033041, compound → HCID 68033046, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-[(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-phenylethyl]-8-({2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)-5,5-dimethyl-4,5-dihydroisoxazolo[4,5-h]quinazoline-3-carboxamide (60 mg, 0.079 mmol) in THF (3 mL), 35% hydrazine in water (0.07 mL) was added and the reaction was warmed at 70° C. for 24 hours. The reaction was cooled at room temperature diluted with H2O (20 mL) and extracted with DCM (2×20 mL). The organic layers were dried over Na2SO4 and the solvent evaporated to dryness to yield the crude solid that was purified by flash chromatography on silica gel (DCM/MeOH/(NH3 7N in MeOH) to afford the title compounds.

Provenance & Evidence