HCID 68033044, compound → HCID 56645430, compound

Participants

Reaction Steps

To a mixture of tert-butyl [(2S)-2-({[8-({2-methoxy-4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)-5,5-dimethyl-4,5-dihydroisoxazolo[4,3-h]quinazolin-3-yl]carbonyl}amino)-2-phenylethyl]carbamate 110 mg (0.151 mmol) in MeOH (1 mL), 0.378 mL of 4 N HCl in dioxane was added. The reaction was stirred at room temperature for 12 h, the solvent was evaporated to dryness and the solid treated with Et2O (20 mL) and the precipitated collected by filtration to give the title compound as a pale yellow solid (96 mg; 91% yield).

Provenance & Evidence