反应详情

2-Nitrocyclohexanone (6.77 g; 47.3 mmol) was dissolved in dried MeOH (150 mL) and a two fold excess by weight of Amberlyst® A21 (13.5 g) was added. The mixture was refluxed under nitrogen for 1.5 h then filtered and evaporated to give 6-nitrohexanoic acid methyl ester (7.72 g; 42 mmol). Yield: 89%.

1. additiona two fold excess by weight of Amberlyst® A21 (13.5 g) was added
2. temperatureThe mixture was refluxed under nitrogen for 1.5 h
3. filtrationthen filtered
4. customevaporated