Tetrahydrofuran → HCID 136047814, compound

Participants

Reaction Steps

At 0° C., to a solution of 58a (0.2 mmol) in 5 mL CH2Cl2 was added a solution of tetrabutylammonium fluoride in THF (1 N, 0.6 mmol) and stirred at RT for around 14 h until reaction was finished by TLC monitor. 67.0% yield. 1H NMR (500 MHz, DMSO-d6) δ 10.1 (s, 1H), 8.51 (s, 1H), 7.85 (d, 2H, J=8.50 Hz), 7.62 (s, 2H), 6.91 (d, 2H, J=8.5 Hz), 3.86 (s, 6H), 3.79 (s, 3H). MS (ESI) m/z 394.1 (M+Na)+, 369.9 (M−H)−.

Provenance & Evidence