HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methoxy-N-methyl-5-phenylfuran-2-carboxamide → (R)-N-methoxy-N-methyl-2-(1-(phenylsulfonyl)-1H-indol-5-yl)-4,5-dihydrothiazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methoxy-N-methyl-5-phenylfuran-2-carboxamide | HCID 17832042 | — |
| Reactant | (R)-2-(1-(Phenylsulfonyl)-1H-indol-5-yl)-4,5-dihydrothiazole-4-carboxylic acid | HCID 53363878 | — |
| Product | (R)-N-methoxy-N-methyl-2-(1-(phenylsulfonyl)-1H-indol-5-yl)-4,5-dihydrothiazole-4-carboxamide | HCID 53363879 | 57.1% |
Reaction Steps
(R)—N-methoxy-N-methyl-2-(1-(phenylsulfonyl)-1H-indol-5-yl)-4,5-dihydrothiazole-4-carboxamide (65a) was prepared from 64a with the same method as used for 38d. 57.1% yield. 1H NMR (500 MHz, CDCl3) δ 7.92 (m, 2H), 7.77 (m, 3H), 7.51 (d, 1H, J=3.0 Hz), 7.46 (t, 1H), 7.35 (t, 1H), 6.61 (d, 1H), 5.58 (br, t, 1H) 3.82 (s, 3H), 3.73 (t, 1H), 3.43 (m, 1H), 3.21 (s, 3H). MS (ESI) m/z 452.1 (M+Na)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09334242B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-09e79199aaa8463da092716111039776 |
| Source note | uspto-grants-2016_05 |