HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-(+)-Cysteine → (2-(1H-Indol-2-yl)thiazol-4-yl)(1H-indol-2-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-(+)-Cysteine | HCID 5862 | — |
| Reactant | 4-(3,4,5-Trimethoxybenzoyl)-2-phenylthiazole | HCID 25227430 | — |
| Reactant | 2-(1H-indol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid | HCID 57516834 | — |
| Product | (2-(1H-Indol-2-yl)thiazol-4-yl)(1H-indol-2-yl)methanone | HCID 136047812 | — |
Reaction Steps
(2-(1H-Indol-2-yl)thiazol-4-yl)(1H-indol-2-yl)methanone (8) was prepared using the similar method as used of compound 1h from 2-(1H-indol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid and cysteine. 1H NMR (500 MHz, CDCl3) δ 9.39 (s, 1H), 8.54 (s, 1H), 8.46 (s, 1H), 8.06 (s, 1H), 8.03 (dd, 1H), 7.66 (d, 1H), 7.51 (d, 1H), 7.41 (d, 1H), 7.33 (t, 1H), 7.29 (d, 1H), 7.15 (t, 1H), 7.09 (d, 1H), 6.72 (s, 1H). MS (ESI) m/z 366.1 (M+Na)+, 341.9 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09334242B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-75d0c85a48a042dfa202984435786898 |
| Source note | uspto-grants-2016_05 |