3,5-Difluoropyridine-4-carbaldehyde → (3,5-Difluoropyridin-4-yl)methanol

HRID 522603Notes

Reaction equation

HRID 522603 reaction equation
FC1C(CO)=NC=CC=1F.[F:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([F:20])[C:17]=1[CH:18]=[O:19]>CO>[F:11][C:12]1[CH:13]=[N:14][CH:15]=[C:16]([F:20])[C:17]=1[CH2:18][OH:19]

Participants

4

Reactant 2

HCID 116511703,5-Difluoropyridine-4-carbaldehydeHCID 68277928(3,4-Difluoro-2-pyridinyl)methanol

Product 1

HCID 66815317(3,5-Difluoropyridin-4-yl)methanolYield 73%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Title compound was prepared by a method analogous to that described for Intermediate 7, replacing 3,4-difluoro-2-pyridinecarbaldehyde with 3,5-difluoro-4-pyridinecarbaldehyde (FRONTIER) and using MeOH as solvent. (200 mg, 1.398 mmol, 73% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm: 8.51 (s, 2H), 5.55 (t, 1H), 4.55-4.57 (m, 2H). [ES+MS] m/z 146 (MH+).

Sources & evidence

ORD record
ord-58cc3fa1698142de9a9ade3f384750de
Source dataset
uspto-grants-2016_05
Patent number
US09334265B2

Reaction notes

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