1,4-Dioxane hydrochloride → HCID 17141140, compound

HRID 522632Notes

Reaction equation

HRID 522632 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[N:6][CH:7]=1.[ClH:21].O1CCOCC1>>[ClH:21].[Br:1][C:2]1[CH:3]=[N:4][C:5]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 21914476tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate

Product 1

HCID 17141140HCID 17141140, compoundYield 94%

Procedure

A solution of tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate (5 g, 14.6 mmol) in 4 M HCl-dioxane (50 mL) was stirred at room temperature for 1 hour. The reaction mixture was concentrated to give 5-bromo-2-(piperazin-1-yl)pyrimidine HCl salt (crude, 3.3 g, 94%) as a white solid. MS (ES+) C8H11BrN4 requires: 242, 244, found: 243, 245 [M+H]+.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-eda15c6ad8334e34ab6afdfafbef8e7b
Source dataset
uspto-grants-2016_05
Patent number
US09334263B2

Reaction notes

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