HCID 40492824, compound → HCID 28803426, compound

HRID 522636Notes

Reaction equation

HRID 522636 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH2:13][C@@H:12]([OH:16])[CH2:11]2)=[CH:6][CH:5]=1)([O-])=O>[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH2:13][C@@H:12]([OH:16])[CH2:11]2)=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 40492824HCID 40492824, compound

Product 1

HCID 28803426HCID 28803426, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

To a solution of (R)-1-(4-nitrophenyl)piperidin-3-ol was added Pd/C. The mixture was stirred under 1 atm H2 at room temperature overnight, and then filtrated through a pad of Celite. The filtrate was concentrated to afford (R)-1-(4-aminophenyl)piperidin-3-ol.

Workup

  1. filtrationfiltrated through a pad of Celite
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-e4cf681fa41f4c6981fd5359e7cd1f30
Source dataset
uspto-grants-2016_05
Patent number
US09334263B2

Reaction notes

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