1,4-Dioxane → HCID 91754452, compound

Participants

Reaction Steps

To a solution of (R)-1-(4-((4-chloro-1,3,5-triazin-2-yl)amino)phenyl)piperidin-3-ol in dioxane was added diisopropylethylamine 5-benzyl-2-(piperazin-1-yl)pyrimidine. The reaction mixture was stirred at room temperature for 2 hours. The solvents were removed, and the residue was washed with methanol (10 mL) to afford (R)-1-(4-((4-(4-(5-benzylpyrimidin-2-yl)piperazin-1-yl)-1,3,5-triazin-2-yl)amino)benzyl)piperidin-3-ol (Compound 165).

Provenance & Evidence