1,4-Dioxane hydrochloride → HCID 131735538, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-(5-benzylpyrimidin-2-yl)piperazine-1-carboxylate (8.0 g, 23.0 mmol) in 1,4-dioxane (30 mL) was dropwise added a solution of 4 M HCl-dioxane (20 mL, 80 mmol). The reaction mixture was stirred at RT overnight, and then concentrated to give 5-benzyl-2-(piperazin-1-yl)pyrimidine HCl salt (10.2 g, crude) as a yellow solid, MS (ES+) C15H18N4 requires: 254, found: 255 [M+H-100]+.

Provenance & Evidence