Water → HCID 118023102, compound

Participants

Reaction Steps

A solution of 2,4-dichloro-1,3,5-triazine (315 mg, 2.1 mmol), 5-benzyl-2-(piperazin-1-yl)pyrimidine (510 mg, 2.0 mmol) and Hunig's base (540 mg, 4.2 mmol) in 1,4-dioxane (6 mL) was stirred at 60° C. for 1 h. LCMS showed the reaction was completed. The reaction mixture was cooled to RT, diluted by water (60 mL), and extracted with ethyl acetate (40 mL×3). The organic layers were combined, washed with water and brine, dried over sodium sulfate, filtered and concentrated to give 1-(2,2-dimethyl-1,3-dioxolan-4-yl)-1H-pyrazol-4-amine (280 mg, crude) as a yellow solid, which was directly used in the next step without further purification. MS (ES+) C18H18ClN7 requires: 367, found: 368 [M+H]+.

Provenance & Evidence