1,4-Dioxane hydrochloride → Phenyl[2-(1-piperazinyl)-5-pyrimidinyl]methanone hydrochloride

Participants

Reaction Steps

To a solution of tert-butyl 4-(5-benzoylpyrimidin-2-yl)piperazine-1-carboxylate (1 g, 2.7 mmol) in dioxane (20 mL) was added 4 M HCl-dioxane (20 mL), and the reaction mixture was stirred at room temperature overnight. LCMS showed the reaction was completed. The mixture was directly concentrated to give phenyl(2-(piperazin-1-yl)pyrimidin-5-yl)methanone HCl salt as a yellowish solid (0.95 g, 90%). MS (ES+) C15H16N4O requires: 268, found: 269 [M+H]+.

Provenance & Evidence