1,4-Dioxane hydrochloride → 5-(cyclopropylethynyl)-2-(piperazin-1-yl)pyrimidine HCl salt

Participants

Reaction Steps

To a solution of tert-butyl 4-(5-(cyclopropylethynyl)pyrimidin-2-yl)piperazine-1-carboxylate (150 mg, 0.46 mmol) in dioxane (3 mL) was added 4 M HCl-dioxane (3 mL), and the reaction mixture was stirred room temperature for 1 hour. LCMS showed the reaction was completed. The reaction mixture was concentrated to afford 5-(cyclopropylethynyl)-2-(piperazin-1-yl)pyrimidine HCl salt as a white solid (100 mg, crude), which was directly used in the next step without further purification. MS (ES+) C13H16N4 requires: 228, found: 229 [M+H]+.

Provenance & Evidence