1-Methylpyrrolidine → HCID 118036082, compound

Participants

Reaction Conditions

Reaction Steps

Add 3-fluoro-3-methyl-butan-1-amine hydrochloride (88 mg, 0.62 mmol) followed by N-methylpyrrolidine (0.065 mL, 0.62 mmol) to a stirred solution of isopropenyl N-[2-fluoro-4-methyl-5-(2-methylaminopyrido[2,3-d]pyrimidin-6-yl)phenyl]carbamate (184 mg, 0.50 mmol) in 1,4-dioxane (5 mL) and heat at 80° C. under N2 overnight. Concentrate and purify on silica eluting with 0-5% MeOH (2N NH3)/DCM. Purify on SCX column eluting with NH3/MeOH to obtain the title compound (219 mg, 70%). MS (m/z): 414.8 (M+1).

Provenance & Evidence