HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 522802Generated: October 29, 2026
Diisopropylethylamine → HCID 178461598, compound
https://huagongshe.com/reaction/522802
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (3R)-3-Methylmorpholine hydrochloride | HCID 57356922 | — |
| Reactant | HCID 178461592 | HCID 178461592 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | (+-)-2-Butanol | HCID 6568 | — |
| Product | HCID 178461598 | HCID 178461598 | — |
Reaction Steps
2-Chloro-6-((R)-3-methyl-morpholin-4-yl)-9H-purine (1.02 g, 4 mmol), diisopropylethylamine (1.40 mL, 8 mmol), and (R)-3-methylmorpholin hydrochloride (826 mg, 6 mmol) were stirred in 2-butanol (5 mL) in a closed microwave tube under argon at 50° C., until all ingredients were dissolved. The reaction was then stirred at 180° C. for 100 hours. The reaction mixture was then cooled to room temperature and diluted with 200 mL of CH2Cl2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09334271B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-b947f4e924834d29af0e3d3298ae2880 |
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| Source note | uspto-grants-2016_05 |
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