Aluminium lithium hydride → HCID 178461597, compound

Participants

Reaction Steps

4-[2,6-Bis-((R)-3-methyl-morpholin-4-yl)-9H-purin-8-yl]-1H-indole-6-carboxylic acid methyl ester (example 32, 72 mg, 146 μmol) was dissolved in 10 ml THF under argon. 1N LiAlH4 in THF (0.22 mL, 0.22 mmol) was added at 5° C., and the reaction was stirred for 2 hours at room temperature. The reaction was quenched by addition of aqueous saturated Na2SO4 (1 mL). The mixture was diluted with 30 mL of CH2Cl2 and 3 mL of isopropanol. The organic phases were separated, dried over Na2SO4, filtered, and concentrated. The residue was purified by column chromatography (12 g SiO2, CH2Cl2/EtOH in a gradient from 100/0 to 88/12) to give the product as a solid (58 mg, 84%).

Provenance & Evidence