反应详情

To a roundbottom flask charged with 3-fluoro-N-methyl-5-nitrobenzamide (961 mg, 4.85 mmol) was added EtOH (16 mL). The resulting suspension was thoroughly purged with nitrogen prior to the addition of 10% Pd/C (43 mg, 0.485 mmol). The reaction mixture was purged with H2 (g), then stirred under 1 atm. H2 balloon at RT. After 2 d, the reaction mixture was filtered through Celite® (diatomaceous earth) with the aid of EtOH and the filtrate was dried under reduced pressure to afford 3-amino-5-fluoro-N-methylbenzamide (825 mg, 4.91 mmol, 100%).

1. customThe resulting suspension was thoroughly purged with nitrogen
2. customThe reaction mixture was purged with H2 (g)
3. customat RT
4. filtrationthe reaction mixture was filtered through Celite® (diatomaceous earth) with the aid of EtOH
5. customthe filtrate was dried under reduced pressure