HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido(4,3-b)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Phenylhydrazine | HCID 7516 | — |
| Reactant | 1-Benzyl-4-piperidone | HCID 19220 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido(4,3-b)indole | HCID 275438 | 95% |
Reaction Steps
1-Benzyl-4-piperidone (1 mmol) was added dropwise to a stirred suspension of phenyl hydrazine (1 equiv.) in a solution of 7% H2SO4 (20 mL) in 1,4-dioxane (20 mL). The reaction mixture was heated at reflux for 18 h then cooled to RT. The solvent was evaporated and the residue recrystallized to afford 2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09334269B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-e799155e81a64b13a45fb0c2ff99f22d |
| Source note | uspto-grants-2016_05 |