Trifluoroacetic acid → Trifluoroacetic acid

Participants

Reaction Steps

To a flask charged with tert-butyl 8-(4-(3-(methylcarbamoyl)phenylamino)-1,3,5-triazin-2-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate (300 mg, 0.642 mmol) was added DCM (5 mL), and TFA (494 mL, 6.42 mmol) respectively. The resulting mixture was stirred overnight at RT. The reaction mixture was concentrated, and the resulting solid was triturated with ethyl acetate to obtain 3-(4-(2,8-diazaspiro[4.5]decan-8-yl)-1,3,5-triazin-2-ylamino)-N-methylbenzamide as a bis-TFA salt (233 mg, 99% yield) as white solid.

Provenance & Evidence