反应详情

To a solution of 3-fluoro-N-methyl-5-nitrobenzamide (500 mg, 2.52 mmoL) in methanol (7.5 mL) was added Pd/C (30%) and the mixture was stirred at RT for 1 h. The reaction mixture was filtered through Celite® (diatomaceous earth), washed with methanol and concentrated under reduced. Purification by silica gel column chromatography provided 3-amino-5-fluoro-N-methylbenzamide (0.300 g, 75%) as a solid.

1. filtrationThe reaction mixture was filtered through Celite® (diatomaceous earth)
2. washwashed with methanol
3. concentrationconcentrated under reduced
4. customPurification by silica gel column chromatography