N-[2-(7-hydroxy-1-naphthyl)ethyl]cyclopropanecarboxamide → N-{2-[7-(cyclohexen-3-yl)oxy-1-naphthyl]ethyl}cyclobutanecarboxamide

HRID 52292Notes

Reaction equation

HRID 52292 reaction equation
O[C:2]1[CH:11]=[C:10]2[C:5](C=CC=C2CCNC(C2CC2)=O)=[CH:4][CH:3]=1.[OH:20][C:21]1[CH:30]=[C:29]2[C:24]([CH:25]=[CH:26][CH:27]=[C:28]2[CH2:31][CH2:32][NH:33][C:34]([CH:36]2[CH2:39][CH2:38][CH2:37]2)=[O:35])=[CH:23][CH:22]=1>>[CH:2]1[CH2:11][CH2:10][CH2:5][CH:4]([O:20][C:21]2[CH:30]=[C:29]3[C:24]([CH:25]=[CH:26][CH:27]=[C:28]3[CH2:31][CH2:32][NH:33][C:34]([CH:36]3[CH2:39][CH2:38][CH2:37]3)=[O:35])=[CH:23][CH:22]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 15149137N-[2-(7-hydroxy-1-naphthyl)ethyl]cyclopropanecarboxamideHCID 18360674N-[2-(7-hydroxy-1-naphthyl)ethyl]cyclobutanecarboxamide

Product 1

HCID 19963467N-{2-[7-(cyclohexen-3-yl)oxy-1-naphthyl]ethyl}cyclobutanecarboxamide

Procedure

Using the procedure described in Example 25, but replacing the compound obtained in Example 24 by the compound obtained in Example 41, N-{2-[7-(cyclohexen-3-yl)oxy-1-naphthyl]ethyl}cyclobutanecarboxamide is obtained.

Sources & evidence

ORD record
ord-156afe07ccb8475b8bde9b08bd00f815
Source dataset
uspto-grants-1997_04
Patent number
US05616614

Reaction notes

Loading…