Cesium carbonate → 3-((5-fluoro-2-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-4-yl)amino)-N-methylbenzamide

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-((2-chloro-5-fluoropyrimidin-4-yl)amino)-N-methylbenzamide (500 mg, 1.78 mmoL) and 3-(4-fluorophenoxy)azetidine (298 mg, 1.78 mmol) in DMA (6 mL, 3 mL/mmoL) was added cesium carbonate (580 mg, 2.67 mmol) and the reaction was degassed for 15 min. Pd2(dba)3 (80 mg, 0.089 mmol) and BINAP (55 mg, 0.089 mmol) and the reaction was allowed to heat at 100° C. in the microwave. The reaction was quenched with water and extracted with EtOAc (2×25 mL). The organic extracts were washed with brine, dried over sodium sulfate and concentrated under reduced pressure then purified by silica gel column chromatography to give 3-((5-fluoro-2-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-4-yl)amino)-N-methylbenzamide (97 mg, 15%) as solid. Observed mass (M+1): 412.1

Provenance & Evidence