反应详情

A mixture of 1,5-dichloroanthraquinone (5.5 g, 20 mmol) and N,N,N′-trimethylethylenediamine (40 ml) was refluxed for 18 h. The mixture was cooled to room temperature, diluted with water (400 mL) and extracted with chloroform (2×200 mL). The combined organic layer was washed with water, brine, dried over MgSO4 and evaporated to dryness. The residue thus obtained was purified by silica gel flash chromatography [CHCl3/MeOH/Et3N (44:5:1)] to provide Compound 9. Abs (max, PBS pH 7.4)=508 nm. The structure of Compound 9 is given below:

1. temperaturewas refluxed for 18 h
2. extractionextracted with chloroform (2×200 mL)
3. washThe combined organic layer was washed with water, brine
4. dry with materialdried over MgSO4
5. customevaporated to dryness
6. customThe residue thus obtained
7. customwas purified by silica gel flash chromatography [CHCl3/MeOH/Et3N (44:5:1)]