HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroaniline → HCID 85910984, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | 3-Fluorobenzaldehyde | HCID 68009 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 85910984 | HCID 85910984 | — |
Reaction Steps
The reaction of 4-fluoroaniline and 3-fluorobenzaldehyde in TFA and acetonitrile provided the N-3-fluorobenzylidene-4-fluoroaniline. The cyclopentadiene was separately prepared from its dimer dicyclopentadiene. The dimer was heated at 180° C. to give monomer, which was reacted with N-3-fluorobenzylidene-4-fluoroaniline in acetonitrile in presence of TFA to provide the desired difluoro compound 100.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09334284B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-f059522e65954bd5ba48a5e5e553125a |
| Source note | uspto-grants-2016_05 |