Dimethylamine, hydrochloride → HCID 118676294, compound

Participants

Reaction Steps

To 50 mg (0.15 mmol) of 44 in 2 mL of DMF is added 58 mg (0.18 mmol) of TBTU, 15 mg (0.18 mmol) of dimethylamine hydrochloride and 0.03 mL (0.2 mmol) of iPr2NEt. The mixture is stirred for 48 h, diluted with 50 mL of EtOAc, and washed twice with 20 mL of H2O and once with 20 mL of brine. The organic phase is dried with MgSO4, filtered, concentrated, and purified twice by preparative TLC (100% EtOAc) to give 22 mg (0.06 mmol) of 46.

Provenance & Evidence