HCID 89995738, compound → HCID 73389684, compound

HRID 523048Notes

Reaction equation

HRID 523048 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]1[CH:13]=[N:14][N:15]([CH2:17][C:18]([CH3:21])([OH:20])[CH3:19])[CH:16]=1)=[CH:7][CH:6]=2.[NH2:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[N:33]3[CH2:34][CH2:35][N:36](C(OC(C)(C)C)=O)[CH2:37][C:32]3=[N:31][CH:30]=2)=[CH:25][C:24]=1[O:45][CH3:46]>>[CH3:46][O:45][C:24]1[CH:25]=[C:26]([C:29]2[N:33]3[CH2:34][CH2:35][NH:36][CH2:37][C:32]3=[N:31][CH:30]=2)[CH:27]=[CH:28][C:23]=1[NH:22][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]1[CH:13]=[N:14][N:15]([CH2:17][C:18]([CH3:21])([OH:20])[CH3:19])[CH:16]=1)=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 89995738HCID 89995738, compoundHCID 90004118HCID 90004118, compound

Product 1

HCID 73389684HCID 73389684, compound

Procedure

The title compound was prepared according to the method described for Example 110 using 1-(1-(4-(3-chloroisoquinolin-6-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol (Preparation 22) and tert-butyl 3-(4-amino-3-methoxyphenyl)-5,6-dihydroimidazo[1,2-a]pyrazine-7(8H)-carboxylate (Preparation 89).

Sources & evidence

ORD record
ord-1ef5d244b91846af94ccfbbf0bf95ead
Source dataset
uspto-grants-2016_05
Patent number
US09334286B2

Reaction notes

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